Publications by authors named "M K Viaene"
Footprint of pancreas infiltrating and circulating immune cells throughout type 1 diabetes development.
Front Endocrinol (Lausanne)
December 2023
Introduction: Type 1 diabetes (T1D) is defined by immune cell infiltration of the pancreas, in particular the islets of Langerhans, referred to as insulitis, which is especially prominent during the early disease stages in association with decreased beta cell mass. An in-depth understanding of the dynamics and phenotype of the immune cells infiltrating the pancreas and the accompanying changes in their profiles in peripheral blood during T1D development is critical to generate novel preventive and therapeutic approaches, as well as to find biomarkers for the disease process.
Methods: Using multi-parameter flow cytometry, we explored the dynamic changes of immune cells infiltrating the pancreas and the pancreatic draining lymph nodes (PLN), compared to those in peripheral blood in female and male non-obese diabetic (NOD) mice during T1D progression.
HLA in isolated REM sleep behavior disorder and Lewy body dementia.
Ann Clin Transl Neurol
September 2023
Article Synopsis
- A study investigated the relationship between the human leukocyte antigen (HLA) locus and synucleinopathies, specifically Lewy body dementia (LBD) and isolated REM sleep behavior disorder (iRBD), which are linked to neuroinflammation.
- It was found that the HLA-DRB1*11:01 allele was significantly associated with iRBD, while several other alleles showed varying associations.
- The results imply that the HLA locus may have distinct roles depending on the type of synucleinopathy being examined.
Article Synopsis
- NPC1 is a gene that encodes a protein crucial for cholesterol transport in lysosomes, and mutations in this gene can cause Niemann-Pick disease type C, a lysosomal storage disorder.
- This study investigated the potential link between NPC1 variants and several alpha synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and rapid eye movement-sleep behavior disorder, using data from multiple cohorts of individuals of European descent.
- The results showed that neither common nor rare NPC1 variants were associated with these neurodegenerative disorders, indicating that NPC1 mutations likely do not significantly impact the development of alpha synucleinopathies.
Article Synopsis
- - The study investigates the role of the human leukocyte antigen (HLA) locus in isolated REM sleep behavior disorder (iRBD), Lewy body dementia (LBD), and Parkinson's disease (PD), highlighting the genetic and neuroinflammatory links between these synucleinopathies.
- - Researchers performed genetic analyses using data from over 1,000 iRBD patients and 2,600 LBD patients to identify associations between specific HLA alleles and disease susceptibility, finding strong links for certain alleles in iRBD but not in LBD.
- - The results indicate a unique association of the HLA allele *11:01 with iRBD, suggesting that the genetic factors may differ between these
Article Synopsis
- * A genome-wide association study identified five genetic risk loci for RBD near specific genes (SNCA, GBA, TMEM175, INPP5F, and SCARB2), suggesting a genetic basis for the disorder.
- * Further analysis indicates that certain genes, like SNCA-AS1, show different expression levels in various brain regions affected by RBD, paving the way for recognizing RBD as a distinct subtype of alpha-synucleinopathy for potential early interventions.