[Erythrocytes and leucocytes in realization of communication between lipid peroxidation and hemostasis].

Investigation of 213 rats has shown that exposition containing normal plasma of erythrocytes, neutrophils or monocytes (physiological concentration) taken from the rats treated with prooxidant (lead acetate) or antioxidant (selmevite) causes corresponding increase or decrease of: a) both spontaneous aggregation and ATP-induced aggregation of thrombocytes, b) releasing P3 and P4 factors, c) their lipoperoxidation (LPO) intensity. The effect is released by LPO products released by erythrocytes and leucocytes into their environment. The efficacy of antioxidants (vitamins with antioxidant properties in particular) used for correcting hypercoagulative changes in oxidative stress in clinics is supposed to be due to their capacity for limiting lipidoxidation in erythrocytes, leukocytes and thrombocytes.

[Effect of different levels of lipid peroxidation on continous intravascular blood coagulation].

Experiments on albino rats revealed that activation or suppression of lipid peroxidation are accompanied by increase or decrease of intravascular blood coagulation. Altered lipid peroxidation influences platelet activity and this influences the rate of intravascular blood coagulation. It is possible that antioxidants may be used for correction of hemostasis under pathological conditions characterized by increased lipid peroxidation.

[The effect of a combined vitamin--antioxidants preparations on hemostasis in rats with experimental hyperperoxidation].

Experiments on a group of 308 rats showed that prooxidant (lead acetate) introduced per os with daily meals decreases the antioxidant potential (increases lipid peroxidation, LPO) and reduces tolerance with respect to thrombin (increases the level of intravascular blood coagulation markers). For the same treatment on the background of a vitamin - antioxidants preparations (complivit or selmevit), the level of changes was significantly decreased and the resistance to thrombin was increased. Selmevit (containing selenium) was more effective.

[Hemostatic disturbances after aorto-femoral and femoro-popliteal bypasses in patients with lower limbs obliterating atherosclerosis].

Forty-seven men aged from 38 to 74 years with lower limb obliterating atherosclerosis (III-IV degree, indication for surgery) were examined. Growth of lipoperoxides level, a decrease of antioxidant potential, activation of hemostasis were revealed. These phenomena intensified after bypass surgeries and persisted till discharge.

[Metabolism of the inhibitor of fibrin self-assembly in rats].

It has been shown that the application of the labelled preparation in physiologically normal white rats and in animals with experimental hyper- and hypothrombinemia leads to the rapid exchange of the peptide self-assembly inhibitor between the blood and extravascular space. The constant level of the inhibitor in the blood is maintained due to continuous supply from tissues and its excretion with the urine. The role and mechanisms of the inhibitor involvement into the maintenance of the liquid state of the blood as a factor limiting the speed of nonenzymatic stage of fibrinogen conversions are suggested.