Combinatorial Effect of Doxorubicin Entrapped in Alginate-Chitosan Hybrid Polymer and Cerium Oxide Nanocomposites on Skin Cancer Management in Mice.

Conventional chemotherapeutic drugs are used for cancer management, but recently nanoparticles have also been shown to contribute towards controlling cancer cell proliferation. In the present study, we focussed on analyzing the combinatorial effect of Cerium oxide (CeO) nanoparticles and Doxorubicin (Dox) on melanoma cancer cells in vitro and in vivo. We entrapped CeO, Dox, and CeO+Dox in a hybrid polymer matrix of alginate and chitosan (Alg-Cs) and used them in both in vitro and in vivo studies to compare their anticancer effect.