Publications by authors named "M K Ryan"
Background: Manual extraction of real-world clinical data for research can be time-consuming and prone to error. We assessed the feasibility of using natural language processing (NLP), an AI technique, to automate data extraction for patients with advanced lung cancer (aLC). We assessed the external validity of our NLP-extracted data by comparing our findings to those reported in the literature.
View Article and Find Full Text PDFObjective: This study aims to map the existing sources of evidence on perioperative care and recovery strategies for primary cleft palate repair, to identify elements that should be included in an enhanced recovery pathway (ERP), and to identify gaps in current knowledge.
Design: Scoping review.
Setting: ERPs are evidence-based, patient-centered, multimodal, perioperative care pathways designed to reduce surgical stress and improve postoperative outcomes and are increasingly being reported in the cleft lip and palate literature.
Tyrosine phosphorylation is an important post-translational modification that regulates many biochemical signaling networks in multicellular organisms. To date, 46,000 tyrosines have been observed in human proteins, but relatively little is known about the function and regulation of most of these sites. A major challenge has been producing recombinant phospho-proteins in order to test the effects of phosphorylation.
View Article and Find Full Text PDFObjective: To better understand critically ill children's lived experiences with family presence in the pediatric intensive care unit (PICU).
Study Design: This qualitative, interpretive phenomenological study is grounded in a Childhood Ethics ontology. We recruited children (aged 6-17 years) admitted to one of four participating Canadian PICUs between November 2021-July 2022 using maximum variation sampling.
Article Synopsis
- The study aimed to evaluate the pediatric Brain Injury Guidelines (pBIG) for identifying pediatric patients with traumatic intracranial hemorrhage (ICH) who may not need further neuroimaging or hospitalization.
- A total of 955 patients were analyzed, with findings showing that the majority had pBIG 2 or 3 injuries, and nearly 40% of those who had repeat imaging showed hemorrhage progression.
- Those meeting pBIG 3 criteria were significantly more likely to need surgical intervention or face higher mortality rates, emphasizing the importance of the guidelines in determining treatment urgency.