Publications by authors named "M K Paik"
Three new depsipeptides, homiamides A-C (-), were isolated from a marine sediment-derived strain of sp., ROA-065. The planar structures of homiamides A-C (-) were elucidated using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data.
View Article and Find Full Text PDFBackground: The KITENIN/ErbB4 complex has been reported to participate in metastasis, which is the principal reason of death in most colorectal cancer patients.
Purpose: New therapeutics need to be developed to suppress the malignant effects of the KITENIN/ErbB4 complex, which is related to drug resistance. The present study aimed to evaluate changes in cancer cell invasion capacity, transcriptional regulators, and cellular bioenergetics after targeting the KITENIN/ErbB4 complex with emodin.
Article Synopsis
- Maternal nutrition during pregnancy has a significant impact on the long-term health of offspring, with potential links to various diseases later in life.
- The study examined the metabolite profiles of male rat offspring resulting from maternal under- and overnutrition compared to a control group, focusing on changes in their plasma metabolites at 16 weeks old.
- Key findings revealed that certain fatty acids related to tryptophan and linoleic acid metabolism were altered in the offspring, suggesting that these changes may increase the risk of metabolic and neurodegenerative diseases tied to their mothers' diets during pregnancy.
Article Synopsis
- Bovine digital dermatitis (BDD) is an infection in cattle that leads to hoof lesions and lameness, primarily driven by treponemes as the main pathogens.
- A study utilizing gas chromatography-mass spectrometry and high-performance liquid chromatography identified significant metabolic changes in organic acids, amino acids, and fatty acids between the pathogens involved.
- Key findings included drastic reductions in certain metabolites like pyruvic acid and glycine, and notable increases in butyric and propionic acids, indicating complex metabolic interactions that may influence the progression of BDD and enhance understanding of its pathogenesis.
Background: Aging is a progressive process characterized by weakness in brain function. Although metabolomics studies on the brain related with aging have been conducted, it is not yet fully understood. A systematic metabolomics study was performed to search for biomarkers and monitor altered metabolism in various brain tissues of the cortex, cerebellum, hypothalamus, and hippocampus of young (8 months old) and old rats (22 months old).
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