Publications by authors named "M K Olesen"
Background: Screening for atrial fibrillation is rising and may worsen or improve quality of life.
Methods: We assessed quality of life (EQ-5D-5L) data in 6,004 participants with stroke risk factors randomised to usual care (n=4,503) or implantable loop recorder with anticoagulation upon detection of atrial fibrillation (n=1,501). Five domains (mobility, selfcare, usual activities, pain/discomfort, anxiety/depression) each scored from one to five were calculated into individual index scores (worst=-0.
Continuous monitoring of pediatric drug utilization is important for ensuring rational use and prioritizing research. This study provides an overview of pediatric prescription drug use among Danish children and adolescents from 2005-2023. Using Danish nationwide individual-level dispensing data, we identified all redeemed prescriptions for individuals < 18 years from January 2005-December 2023.
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- Autism spectrum disorder (ASD) is linked to mitochondrial dysfunction, which involves increased mitochondrial DNA (mtDNA) copy number and energy production issues; this study focused on key genes related to mtDNA replication to understand their role in ASD.
- Children with ASD showed higher mtDNA copy numbers and some mtDNA deletions in oral samples, but no significant changes were found in the expression of mitochondrial replisome genes compared to typically developing controls.
- Increased oxidative stress and inflammation were noted in ASD subjects, and while overexpressing the TFAM gene in cell cultures led to some mitochondrial benefits, this didn't directly tie to changes in gene expression or mtDNA integrity, indicating a complex relationship between mitochondrial dysfunction and ASD.
Genetic Testing in Atrial Fibrillation Patients: Potential to Enhance Clinical Outcome Prediction.
JACC Clin Electrophysiol
November 2024
X-linked adrenoleukodystrophy (ALD) is a rare metabolic disorder. Symptoms range from cerebral demyelination (cALD) to adrenal insufficiency and slowly progressive myeloneuropathy. cALD is fatal if not treated with hematopoietic cell transplantation in the early stages of the disease course.
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