Publications by authors named "M K Navya"

Article Synopsis
  • - Lamins, specifically Lamin A/C, are proteins found in the inner nuclear membrane that provide structural support to the nucleus and play a key role in gene expression and chromatin organization.
  • - The expression of Lamin A/C varies across different tissues, being higher in hard tissues like bone and muscle, and it’s crucial for maintaining cellular function; mutations in the LMNA gene can lead to diseases such as muscular dystrophy and cardiomyopathies.
  • - This review explores the structure, expression patterns, and functions of Lamin A/C, especially its role in cardiovascular diseases, while suggesting potential therapeutic interventions to address related symptoms.
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Congenital insensitivity to pain (CIP) is a rare autosomal recessive genetic condition which causes reduced pain sensation, thermal sensation, and habit of self-mutilation. It is a life-threatening condition where due to reduced pain sensation, patient might not understand the severity of the injury which can eventually lead to death. Such people live a compromised life and can also affect them psychologically.

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Unlabelled: Dispersions having chickpea (37%, 40%, and 43%, w/w) and gum arabic (0%, 1%, 2%, 3%, 4%, and 5%, w/w) solids were prepared. These dispersion droplets were fried, and the physical, sensory, and microstructural characteristics of the fried products were determined. The oil content in the fried snack decreased up to 20.

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Article Synopsis
  • The research focused on creating a pH-sensitive co-polymer, specifically poly acrylamide-grafted-guar gum (PAAm-g-GG), through a chemical modification process known as free radical polymerization.
  • Esomeprazole magnesium (ESO) was used to formulate intestinal-targeted nanoparticles (NPs) using this co-polymer, involving a nano-emulsification polymer crosslinking method which resulted in nanoparticles of varying sizes (200-600 nm).
  • The study found that drug release from the nanoparticles was significantly influenced by the surrounding pH, showing delayed release in acidic conditions while allowing gradual release in alkaline conditions, with the nanoparticles displaying uniform size and smooth surface characteristics.
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