EXPRESS: Loss and damage in large-diameter sensory neurons in the db/db diabetic mouse.

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes. Half of DPN patients experience sensory deficits including loss of sensation and pain. Loss of sensation increases the risk of unnoticed foot injuries which combined with poor circulation and healing lead to amputation.

Clinical and ultrasonographic features of 104 knee joints in hemodialysis patients: impact of age, gender, and hemodialysis duration: a descriptive cross-sectional study.

Background And Objectives: Hemodialysis (HD) patients struggle with musculoskeletal disorders. This study aimed to examine knee clinical and musculoskeletal ultrasonographic (MSUS) characteristics in HD patients and to evaluate the influence of age, gender, and HD duration.

Materials And Methods: This cross-sectional descriptive study included 52 patients (104 knee joints) on regular HD for at least 6 months.

Heart Transplantation and Donation After Circulatory Death in Children. A Review of the Technological, Logistical and Ethical Framework.

Heart transplant for adults following Donation after Circulatory Death (DCD) is well established in many parts of the world, including the United Kingdom (UK). Small child DCD hearts have now been recovered in the UK and internationally utilising novel technologies. Despite these recent advances, extension of this practice to pediatric cardiac transplantation has been slow and difficult despite the severe shortage of donors for children leading to a high number of deaths annually of children waiting for heart transplant.

The prognostic impact of PBRM1 immunohistochemical expression and its association with CD3 + and CD8 + immune cells in patients with renal cell carcinoma: A retrospective study.

The objective of this study is to determine the prognostic implications of PBRM1 immunohistochemical (IHC) expression in renal cell carcinoma (RCC) patients. Additionally, the objective is extended to evaluate the association between PBRM1 expression and CD3 + and CD8 + immune infiltrates. This study retrospectively reviewed 115 RCC patients who underwent nephrectomy.

Differences in learning across the lifespan emerge via resource-rational computations.

Learning accurate beliefs about the world is computationally demanding but critical for adaptive behavior across the lifespan. Here, we build on an established framework formalizing learning as predictive inference and examine the possibility that age differences in learning emerge from efficient computations that consider available cognitive resources differing across the lifespan. In our resource-rational model, beliefs are updated through a sampling process that stops after reaching a criterion level of accuracy.