Effective governance is crucial for the success of conservation projects aimed at protecting wildlife populations and supporting human well-being. However, few large-scale, comprehensive syntheses have been conducted on the effects of different environmental governance types on conservation outcomes (i.e.
View Article and Find Full Text PDFGlioblastoma (GBM) is driven by malignant neural stem-like cells that display extensive heterogeneity and phenotypic plasticity, which drive tumor progression and therapeutic resistance. Here, we show that the extracellular matrix-cell adhesion protein integrin-linked kinase (ILK) stimulates phenotypic plasticity and mesenchymal-like, invasive behavior in a murine GBM stem cell model. ILK is required for the interconversion of GBM stem cells between malignancy-associated glial-like states, and its loss produces cells that are unresponsive to multiple cell state transition cues.
View Article and Find Full Text PDFPurpose: Cancer is a leading cause of global childhood mortality, affecting 400,000 children annually. While treatable with modern therapies, children living in low- and middle-income countries (LMICs) have limited access to care and lower survival rates. Hospital-based cancer registries (HBCRs) collect detailed patient information to critically evaluate and evolve care.
View Article and Find Full Text PDFUnderstanding the extent of salt-affected soils is important in agriculture for irrigation, crop selection and land management, and affordable smartphone-based techniques can broaden access to environmental analysis in resource-limited settings. A novel smartphone-based Digital Image Colorimetry (DImC) technique using colorimetric chloride test strips has been developed and compared to 3 other field techniques (direct soil conductivity (), soil extract solution conductivity (), titration test strips (TS)) and 1 lab-based method (chloride analyser (CA)) for the assessment of soil salinity. A survey of soils from a coastal saltmarsh and neighbouring farmland was conducted in Southwest Scotland and a rapid sample preparation method suitable for in-field use was evaluated.
View Article and Find Full Text PDFBackground: The role of aprotinin in modern cardiac surgery is not well defined. While licensed for use in isolated coronary artery bypass grafting it is more commonly used for cases deemed to be at an increased risk of bleeding. The relative efficacy, and safety profile, of aprotinin as compared to other antifibrinolytics in these high-risk cases is uncertain.
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