Publications by authors named "M K Mathai"
Aims: Cisplatin is a frontline chemotherapeutic utilized to attenuate multiple cancers in the clinic. Given its side-effects, a new cisplatin formulation which could prevent cytotoxicity, metabolic deficiencies and metastasis is much needed. This study investigates whether nanocarriers can provide a better mode of drug delivery in preclinical cancer models seeking a potent anticancer therapeutic agent.
View Article and Find Full Text PDFBackground: Obesity is a risk factor for developing cardiovascular diseases (CVDs) by impairing normal vascular function. Natural products are gaining momentum in the clinical setting due to their high efficacy and low toxicity. extract (CFE) has been shown to control appetite and promote weight loss; however, its effect on vascular function remains poorly understood.
View Article and Find Full Text PDFImplementation of maternal death audits and changes in maternal health care in Cambodia, 2010-2017.
Western Pac Surveill Response J
December 2024
Objective: Cambodia is one of seven countries globally that met Millennium Development Goal 5A: reduction of maternal deaths by at least 75% between 1990 and 2015. The maternal death audit (MDA) was instituted in 2004 to support the improvement of maternal care. We evaluated progress in MDA implementation and maternal health services in Cambodia between 2010 and 2017.
View Article and Find Full Text PDFArticle Synopsis
- Urbanization and varying microclimates in cities affect mosquito behavior and malaria transmission, particularly in urban slums.
- This study analyses how different household roof types (thatched, asbestos, tiled) impact the survival of Anopheles stephensi mosquitoes and the development of Plasmodium vivax.
- Findings reveal that thatched roofs promote higher parasite development and mosquito survival compared to asbestos and tiled roofs, highlighting the significance of environmental factors in malaria control strategies.
Article Synopsis
- A mental health study in western Kenya tested the feasibility of delivering treatments for major depression and PTSD through non-specialist staff in primary care settings, incorporating both in-person and mobile health (mHealth) options due to the COVID-19 pandemic.
- The chosen intervention involved either psychotherapy (Interpersonal Psychotherapy) or medication (fluoxetine), with 2,162 public sector primary care patients participating.
- A secondary analysis assessed participants' preferences for mHealth or in-person treatment, exploring their reasons for choosing one method over the other and comparing demographic and clinical characteristics between the two groups.