Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of .

Members of the complex (MAC) are characterized as nontuberculosis mycobacteria and are pathogenic mainly in immunocompromised individuals. MAC strains show a wide genetic variability, and there is growing evidence suggesting that genetic differences may contribute to a varied immune response that may impact the infection outcome. The current study aimed to characterize the genomic changes within isolates collected from single patients over time and test the host immune responses to these clinical isolates.