Handheld blue light three-dimensional (3D) scanner versus lateral cephalometry for facial morphology assessment in obstructive sleep apnoea participants : Handheld blue light three-dimensional (3D) scanner for facial morphology assessment of obstructive sleep apnoea participants.

Purpose: The main purpose of this study is to evaluate the facial morphology of obstructive sleep apnoea (OSA) individuals by using a handheld blue light three-dimensional (3D) scanner (HBL-3DS) in comparison to conventional lateral cephalometric radiography (LCR). Moreover, our research question is to explores the correlation between 3D facial and neck measurements with OSA indices, encompassing the hypoxic burden.

Method: This prospective cross-sectional study included forty-four adults with OSA.

High-throughput screening identifies a novel small-molecule modulator of Hsp70 that selectively enhances ubiquitination and degradation of misfolded neuronal NO synthase.

The Hsp90 and Hsp70 chaperones act as a protein quality control system for several hundred client proteins, including many implicated in neurodegenerative disorders. Hsp90 and Hsp70 are widely thought to be important drug targets. Although many structurally distinct compounds have been developed to target Hsp90, relatively few are known to target Hsp70 and even fewer have been tested in protein quality control systems.

Atypical memory B cells acquire Breg phenotypes in hepatocellular carcinoma.

The functional plasticity of tumor-infiltrating B (TIL-B) cells spans from anti-tumor responses to non-canonical immune suppression. Yet, how tumor microenvironment (TME) influences TIL-B development is still underappreciated. Our current study integrated single cell transcriptomics and BCR (B cell receptor) sequencing to profile TIL-B phenotypes and clonalities in hepatocellular carcinoma (HCC).

Evaluation of alcohol intoxication on primary and secondary haemostasis - results from comprehensive coagulation testing.

Background: Alcohol intoxication is known to affect blood coagulation. The specific effects remain poorly understood. Here, we investigate the impact of severe alcohol intoxication on blood clotting by comprehensive coagulation testing.