Publications by authors named "M K Lassen"
Background: Despite evidence demonstrating that influenza vaccination is associated with reduced risk of cardiovascular events and all-cause mortality in individuals with diabetes mellitus (DM), vaccine uptake remains suboptimal.
Objectives: The purpose of this study was to assess the effectiveness of electronically delivered nudges on influenza vaccine uptake according to the presence of DM status versus other chronic diseases.
Methods: NUDGE-FLU-CHRONIC was a nationwide, randomized, pragmatic implementation trial among younger and middle-aged (18-64 years) Danish citizens with chronic disease during the 2023/2024 influenza season.
Whether DNA methylation changes follow human physical trauma is uncertain. We aimed to investigate if severe trauma was associated with DNA methylation changes. In a prospective, observational, clinical study, we included severely injured adults and adults undergoing elective surgery (controls).
View Article and Find Full Text PDFArticle Synopsis
- Global longitudinal strain (GLS) is an important indicator of heart failure risk, but analyzing the entire strain curve may uncover additional valuable information about heart health.
- This study used unsupervised machine learning (uML) to examine strain curves from over 3700 participants, finding 10 distinct clusters that revealed unique patterns predicting heart failure risk independent of GLS.
- One specific cluster (cluster 9) showed a significant association with heart failure, even among younger and seemingly healthier individuals, indicating that other strain characteristics beyond peak GLS value are crucial for risk assessment.
Inhaled Corticosteroids Particle Size and Risk of Hospitalization Due to Exacerbations and All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease. A Nationwide Cohort Study.
Int J Chron Obstruct Pulmon Dis
October 2024
Article Synopsis
- A study compared the effects of extra-fine particle inhaled corticosteroids (ICS) to standard particle size ICS on patients with chronic obstructive pulmonary disease (COPD) from 2010 to 2017, focusing on exacerbations needing hospitalization and overall mortality rates.
- Of the nearly 40,500 patients analyzed, the results showed that extra-fine particle ICS did not significantly lower the risk of hospitalizations or all-cause mortality compared to standard ICS; however, a subgroup of patients using pressurized metered dose inhalers (pMDIs) did report reduced risks.
- The findings suggest that while extra-fine particle ICS may not generally offer protective benefits, they could be beneficial for specific patients