Publications by authors named "M K Kharel"

Widespread vagal activation following honey consumption is a sign of mad honey poisoning. Early initiation and appropriate treatment can prevent fatal outcomes.

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Key Clinical Message: Early initiation of anti-retroviral treatment and prompt management of heart failure in a AIDS patient is crucial. If resources available endomyocardial biopsy can guide the future management.

Abstract: HIV-associated cardiomyopathy (HIVAC) is a serious complication of HIV with poorly understood pathology.

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Unlabelled: Hypocalcemia is one of the rarest causes of reversible cardiomyopathy. Patients with refractory heart failure need to be explored for hypocalcemia and need prompt correction.

Abstract: Hypocalcemia is a rare cause of reversible dilated cardiomyopathy.

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Article Synopsis
  • - The FDA approved lecanemab for treating Alzheimer's disease in January 2023, prompting a review of its effectiveness and safety based on existing clinical studies.
  • - A systematic literature search identified three randomized controlled trials, indicating lecanemab reduces clinical decline and brain amyloid-beta plaques, while also increasing the risk of specific adverse effects known as ARIA-H and ARIA-E.
  • - Although lecanemab shows a positive impact on key Alzheimer's indicators, additional research is recommended to assess whether its benefits outweigh the risks associated with its use.
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