Differentiating Choroidal Melanomas and Nevi Using a Self-Supervised Deep Learning Model Applied to Clinical Fundoscopy Images.

Purpose: Testing the validity of a self-supervised deep learning (DL) model, RETFound, for use on posterior uveal (choroidal) melanoma (UM) and nevus differentiation.

Design: Case-control study.

Subjects: Ultrawidefield fundoscopy images, both color and autofluorescence, were used for this study, obtained from 4255 patients seen at the Liverpool Ocular Oncology Center between 1995 and 2020.

Developing a patient toolkit for opioid use and management through co-creation.

Canada has been experiencing an opioid use crisis, and urgent efforts are being made to stem the tide. With funding support from Health Canada, the Association of Faculties of Medicine of Canada (AFMC) recently developed a series of asynchronous online bilingual modules to educate key players across the medical education spectrum on chronic pain and opioid use. The curriculum for the modules which informed the development of the Patient-Physician Partnership Toolkit was co-created through an authentic collaboration between healthcare professionals (HCPs), and patient subject matter experts who were patients with lived experience.

Making Deception Fun: Teaching Autistic Individuals How to Play Friendly Tricks.

Perspective taking is a critical repertoire for navigating social relationships and consists of a variety of complex verbal skills, including socially adaptive forms of deception. Detecting and being able to use socially adaptive deception likely has many practical uses, including defending oneself against bullying, telling white lies to avoid hurting others' feelings, keeping secrets and bluffing during games, and playing friendly tricks on others. Previous research has documented that some Autistic children have challenges identifying deception and playfully deceiving others (Reinecke et al.

Shift work schedules alter immune cell regulation and accelerate cognitive impairment during aging.

Background: Disturbances of the sleep-wake cycle and other circadian rhythms typically precede the age-related deficits in learning and memory, suggesting that these alterations in circadian timekeeping may contribute to the progressive cognitive decline during aging. The present study examined the role of immune cell activation and inflammation in the link between circadian rhythm dysregulation and cognitive impairment in aging.

Methods: C57Bl/6J mice were exposed to shifted light-dark (LD) cycles (12 h advance/5d) during early adulthood (from ≈ 4-6mo) or continuously to a "fixed" LD12:12 schedule.

A Qualitative Exploration of the Process and Experience of Change in Moving on in My Recovery: An Acceptance and Commitment Therapy Based Recovery Group for Substance Use Disorder.

Moving on in my recovery (MOIMR) is a new, acceptance and commitment therapy (ACT) based group intervention to support recovery from substance use disorder. It was co-developed by, and is co-facilitated with, people in recovery. This study used a grounded theory model to understand the process of change experienced by individuals who completed the group programme.