Synthesis, structural characterisation, and anticancer potential of mono and dinuclear Pd(II) complexes of -(2-pyridyl)thiourea.

Cancer is a prominent global cause of mortality. Palladium complexes have the potential to serve as effective anticancer and pharmacological agents, offering a viable alternative to platinum medications. This work focused on the development of a new thiolato-bridged dinuclear [Pd(M3MPyThU)Cl]2 and mononuclear palladium [Pd(M3MPyThU)2] complexes containing 1-methyl-3-(3-methylpyridin-2-yl) thiourea (HM3MPyThU) ligand.

Isolation of potassium salt of oxadiazole-2-thione and anticancer activities of its Cu(II) and Zn(II) complexes against MDA-MB-231 human breast carcinoma cells.

A potassium 4-(pyridyl)-1,3,4-oxadiazole-2-thione was isolated in a basic medium, and its complexes [Cu(en)(pot)] (1) and [Zn(en)(pot)]HBr·CHOH (2) containing ethylenediamine (en) as secondary ligand were synthesized and fully characterized. Upon changing the reaction conditions, the Cu(II) complex (1) adopts an octahedral geometry around the metal center. The cytotoxic activity of ligand (Kpot·HO) along with complexes 1 and 2 was tested, and their anticancer activity against MDA-MB-231 human breast cancer cells was demonstrated, with complex 1 exhibiting superior cytotoxicity against these cells as compared to Kpot·HO and complex 2.

Cobalt (III) complex exerts anti-cancer effects on T cell lymphoma through induction of cell cycle arrest and promotion of apoptosis.

Purpose: Cobalt-based compounds are emerging as a non-platinum-based anti-cancer effective therapeutic agent. However, there is a limited study regarding the therapeutic efficacy of Cobalt-based drugs against Non-Hodgkin's Lymphoma (NHLs) such as T cell lymphoma. Therefore, in the present study we investigated the anti-tumor role of cobalt(III) complex [Co(ptsm)NH(o-phen)]·CHOH on Dalton's Lymphoma (DL) cells.