Controlled synthesis of ternary acrylamide/sodium acrylate/polyethyleneglycol hybrids by integrating different clays and fillers: a comprehensive evaluation of structural features.

A series of anionic poly(acrylamide--sodium acrylate)/poly(ethylene glycol), PAN/PEG, hybrids were conveniently synthesized free radical aqueous polymerization by integrating bentonite, kaolin, mica, graphene and silica, following a simple and eco-friendly crosslinking methodology. A comparative perspective was presented on how integrated nanofillers affect the physicochemical properties of hybrid gels depending on the differences in their structures. Among the five types of nanofillers, bentonite-integrated hybrid gel had the highest water absorbency, while graphene-integrated gel had the lowest.

Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study.

Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart of care for first- and second-line therapies in combination with endocrine therapy (ET) for HR+/HER2- metastatic breast cancer (MBC) patients. It has been reported that combination therapy is more effective than ET alone and is safe in elderly patients as well as young patients. Nevertheless, elderly and very old patients with HR+/HER2-MBC treated with CDK4/6 inhibitor (CDK4/6i) combinations are relatively underrepresented in randomized controlled trials.

Molecular modeling and cytotoxic activity studies of oxirane-2-carboxylate derivatives.

In this study, five 3-aryloxirane-2-carboxylate derivatives were prepared, and the antiproliferative activities of molecules were screened in lung and colon cancer cell lines. The results showed that molecules had antiproliferative activity on cancerous cells with IC values under 100 µM. Furthermore, all of the molecules were found to have a much higher cytotoxic effect than cisplatin in colon cancer cells.

Navigating Concurrent Disasters: Lessons learned from a Hospital Evacuation Amidst a Pandemic and an Earthquake.

The concurrent challenges of the COVID-19 pandemic and a significant earthquake in Izmir on October 30, 2020, presented a unique scenario for disaster management and response. This study focuses on the impact of the earthquake, which resulted in 117 fatalities, including 1 due to drowning, and injured 1034 individuals, alongside widespread structural damage including to the Izmir Democracy University Buca Seyfi Demirsoy Training and Research Hospital. The objective is to assess the activation and implementation of the hospital disaster plan amidst the ongoing pandemic.