Publications by authors named "M K Dahle"
Infectious Salmon Anaemia virus (ISAV) is an orthomyxovirus that causes large economic losses in Atlantic salmon (Salmo salar L.) aquaculture. All virulent ISAV variants originally emerged from a non-virulent subtype, ISAV-HPR0.
View Article and Find Full Text PDFPiscine orthoreovirus (PRV) infection is common in aquaculture of salmonids. The three known PRV genotypes (PRV-1-3) have host species specificity and cause different diseases, but all infect and replicate in red blood cells (RBCs) in early infection phase. PRV-1 is the causative agent of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar), PRV-2 causes erythrocytic inclusion body syndrome (EIBS) in coho salmon (Oncorhynchus kisutch), while PRV-3 induces HSMI-like disease in farmed rainbow trout (Oncorhynchus mykiss).
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- Triple negative breast cancer (TNBC) poses treatment challenges due to chemotherapy resistance and tumor diversity, prompting researchers to identify molecular pathways and patient sub-groups for targeted therapies.
- Using RNA sequencing and reverse phase protein analysis on patient-derived xenografts, the study discovered that signaling pathways like SRC-family kinases (SFKs) and MAPK/ERK are more active in chemotherapy-resistant tumors, indicating potential targets for treatment.
- High expression of these pathways correlates with poor outcomes in some TNBC patients, suggesting that those with elevated SFK levels, particularly in metastatic lesions, could benefit from future SFK-targeted therapies.
Article Synopsis
- Scientists studied how PRV-1, a virus, affects Atlantic salmon by looking for specific signs in their blood called metabolites.
- They compared healthy salmon with sick ones at different stages of the disease to see how the virus changed things inside the fish.
- They found that the virus really messed up the way fats are processed in the salmon’s body, which helped them learn more about how the disease develops.
Article Synopsis
- Farmed rainbow trout can have color changes in their meat, similar to farmed Atlantic salmon, but we didn’t know much about them before this study.
- Researchers looked at 1293 rainbow trout in Norway when they were being slaughtered and found that these changes (called MFCs) happen in about 1.46% to 6.47% of the fish.
- They discovered some viruses related to these changes, but the type of damage looked different in rainbow trout compared to Atlantic salmon, which might explain why rainbow trout don't have these issues as often.