Publications by authors named "M K Cosgrove"
Article Synopsis
- Sleep plays a vital role in health and well-being, with many people experiencing sleep deprivation and chronic insomnia, leading to serious health issues.
- Understanding sleep architecture and hygiene is essential for maintaining physiological functions and overall homeostasis.
- The course targets certified registered nurse anesthetists, providing insights into the relationship between sleep and health, risk factors for chronic sleep deprivation, and treatment options like propofol-induced sleep.
Article Synopsis
- Visual arrestin 1 (Arr1) is crucial for stopping the light response in photoreceptors, and while its dimer and tetramer formations have been studied in mammals, similar research in amphibians is lacking.
- In this study, the dimerization of Arr1 from two amphibian species, Xenopus laevis and Ambystoma tigrinum, revealed that both proteins primarily form dimers with similar dissociation constants (K) to mammalian Arr1.
- Crystallography and other techniques identified two potential dimer structures for amphibian Arr1, suggesting that the interaction between dimer forms may influence their stability and that the distribution of Arr1 in dark-adapted photoreceptors is impacted by
Our understanding of acute leukemia pathology is heavily dependent on 11q23 chromosomal translocations involving the mixed lineage leukemia-1 (MLL1) gene, a key player in histone H3 lysine 4 (H3K4) methylation. These translocations result in MLL1-fusion (MLL1) proteins that are thought to drive leukemogenesis. However, the mechanism behind increased H3K4 trimethylation in MLL1-leukemic stem cells (MLL1-LSCs), following loss of the catalytic SET domain of MLL1 (known for H3K4 monomethylation and dimethylation) remains unclear.
View Article and Find Full Text PDFApproximately 0.6% of the United States population identifies as transgender or gender nonbinary. The term transgender refers to a person who experiences incongruence between their sex at birth and their gender identity.
View Article and Find Full Text PDFSuperior orbital fissure narrowing and tumor-associated pain in spheno-orbital meningiomas.
Acta Neurochir (Wien)
February 2024
Introduction: Spheno-orbital meningiomas (SOMs) represent a distinct subtype of meningioma characterized by their unique multi-compartmental invasion pattern. Previous studies have investigated correlations between SOMs and visual manifestations. However, our comprehension of pain associated with SOMs remains limited.
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