Publications by authors named "M K Chaney"
Purpose: Brentuximab vedotin (BV) is hypothesized to selectively deplete T regulatory cells (Tregs) that express CD30 and re-sensitize tumors to anti-(PD-1) therapy. This study evaluated responses to BV+pembrolizumab post PD-1 and explored corresponding biomarkers.
Methods: 55 patients with metastatic non-small cell lung cancer (NSCLC) and 58 with metastatic cutaneous melanoma received ≥1 dose of BV+pembrolizumab.
Article Synopsis
- Postural orthostatic tachycardia syndrome (POTS) mainly affects young females during puberty and early adulthood, leading to symptoms like lightheadedness, palpitations, weakness, and fatigue.
- These symptoms not only affect daily life but also contribute to mental health issues such as anxiety and depression, highlighting the importance of support in academic environments.
- There is a lack of research and standardized treatment guidelines for POTS, indicating a need for increased awareness, collaboration among healthcare professionals, educators, and policymakers to improve care for affected individuals.
Background: Acute kidney injury (AKI) is a major health burden after cardiac surgery. Renal vasoconstriction and venous congestion can be assessed via transesophageal echocardiography (TEE). The primary objective is to determine feasibility of measuring intraoperative Renal resistive index (RRI) and portal vein pulsatility fraction (PF) by TEE.
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