Histological Evaluation of the Effects of Intra-Articular Injection of Caffeic Acid on Cartilage Repair in a Rat Knee Microfracture Model.

BACKGROUND Cartilage injuries are challenging to treat due to limited self-healing. Standard treatments often lead to the formation of less durable fibrocartilage. Caffeic acid phenethyl ester (CAPE), a polyphenolic compound, can improve cartilage repair.

Enhancing patient information texts in orthopaedics: How OpenAI's 'ChatGPT' can help.

Purpose: The internet has become a primary source for patients seeking healthcare information, but the quality of online information, particularly in orthopaedics, often falls short. Orthopaedic surgeons now have the added responsibility of evaluating and guiding patients to credible online resources. This study aimed to assess ChatGPT's ability to identify deficiencies in patient information texts related to total hip arthroplasty websites and to evaluate its potential for enhancing the quality of these texts.

Microstructural Changes in Intraretinal Layers and Macular Structures of People with Epilepsy Measured Using Optical Coherence Tomography.

Introduction: Epilepsy is a network disorder that can cause alterations in retinal morphology due to microstructural changes in the brain. The aim of our study was to use spectral optical coherence tomography (OCT) to assess the possible effects of neuronal degeneration on the intraretinal layers and macular structures of people with epilepsy and epilepsy subgroups.

Methods: We enrolled 52 consecutive people with epilepsy (37 females, 15 males; mean age 29.

Kinetic characterization of two neuraminic acid synthases and evaluation of their application potential.

Neuraminic acid synthases are an important yet underexplored group of enzymes. Thus, in this research, we performed a detailed kinetic and stability analysis and a comparison of previously known neuraminic acid synthase from Neisseria meningitidis, and a novel enzyme, PNH, obtained from a metagenomic library. A systematic analysis revealed a high level of similarity of PNH to other known neuraminic acid synthases, except for its pH optimum, which was found to be at 5.