Phthalates Impair Estrogenic Regulation of HIF2α and Extracellular Vesicle Secretion by Human Endometrial Stromal Cells.

Di(2-ethylhexyl) phthalate (DEHP), a known endocrine-disrupting chemical, is a plasticizer found in many common consumer products. High levels of DEHP exposure have been linked to adverse pregnancy outcomes, yet little is known about how it affects human uterine functions. We previously reported that the estrogen-regulated transcription factor hypoxia-inducible factor 2 alpha (HIF2α) promotes the expression of Rab27b, which controls the trafficking and secretion of extracellular vesicles (EVs).

Spin-Polarized Scanning Tunneling Microscopy Measurements of an Anderson Impurity.

We report spin-polarized scanning tunneling microscopy measurements of an Anderson impurity system in MoS_{2} mirror-twin boundaries, where both the quantum-confined impurity state and the Kondo resonance resulting from the interaction with the substrate are accessible. Using a spin-polarized tip, we observe magnetic-field-induced changes in the peak heights of the Anderson impurity states as well as in the magnetic-field-split Kondo resonance. Quantitative comparison with numerical renormalization group calculations provides evidence of the notable spin polarization of the spin-resolved impurity spectral function under the influence of a magnetic field.

The degradation of polylactic acid face mask components in different environments.

The disposal of fossil fuel-based plastics poses a huge environmental challenge, leading to increased interest in biodegradable alternatives such as polylactic acid (PLA). This study focuses on the environmental impact and degradation of PLA face mask components under various conditions (UV (Ultraviolet) radiation, DI water, landfill leachate of various ages, seawater, and enzyme). Under UV exposure, notable changes in physicochemical properties were observed in the PLA masks, including increased oxidation over time.

Long-term dietary exposure to a mixture of phthalates enhances estrogen and beta-catenin signaling pathways, leading to endometrial hyperplasia in mice.

Phthalates, synthetic chemicals widely utilized as plasticizers and stabilizers in various consumer products, present a significant concern due to their persistent presence in daily human life. While past research predominantly focused on individual phthalates, real-life human exposure typically encompasses complex mixtures of these compounds. The cumulative effects of prolonged exposure to phthalate mixtures on uterine health remain poorly understood.

A critical insight into the physicochemical stability of macular carotenoids with respect to their industrial production, safety profile, targeted tissue delivery, and bioavailability.

Lutein, zeaxanthin, and mesozeaxanthin, collectively termed as macular pigments, are key carotenoids integral to optimized central vision of the eye. Therefore, nutraceuticals and functional foods have been developed commercially using carotenoid rich flowers, such as marigold and calendula or single celled photosynthetic algae, such as the Dunaliella. Industrial formulation of such products enriched in macular pigments have often suffered from serious bottlenecks in stability, delivery, and bioavailability.