[The effect of exogenous lipids on the functional activity of the liver in experimental hepatitis].

Content of lipids in blood serum and membranes of liver tissue endoplasmic reticulum, functional activity of microsomes, antitoxic activity of liver tissue as well as collagen production in rat liver tissue were studied in experimental hepatitis after administration of exogenous lipids (equine erythrocyte phospholipids and ganglioside GM3, bovine spinal cord phospholipids). All the preparations studied inhibited the functional activity of the liver cells which was expressed as a decrease of the lipids content in the microsomes, inhibition of glucose-6-phosphate dehydrogenase activity and impairment of the liver tissue antitoxic functions. Distinct inhibition of these reactions caused an increase of the collagen content in the liver tissue.

[The effect amniocen preparation on nucleic acid metabolism in rat liver cells].

Rates of DNA and RNA synthesis as well as transport of RNA into cytoplasmic structures of rat liver cells were studied after administration of amniocen preparation. The drug did not affect the rate of DNA and RNA synthesis in intact rat liver cells, while specific radioactivity of DNA was decreased in regenerating liver tissue 24 hrs after hepatectomy. Amniocen inhibited the rate of rRNA, mRNA and tRNA transport into cytoplasm but contributed to elevated penetration of nucleic acid precursors into rat liver cells.