Publications by authors named "M Jurado"

The increasing use of mulching films in intensive agriculture, together with their inefficient end-of-life disposal, has led to a significant plastic accumulation in soils, which contributes to disrupting ecosystems. The aim of this work was to determine the ability of different sustainable carriers to harbor and introduce plastic-degrading microorganisms into contaminated soils to provide a biotechnological tool that potentially enhances plastic decontamination, ameliorating the harmful effect of this type of pollutant in soil. To this end, pure cultures and co-cultures of Bacillus subtilis and Pseudomonas alloputida (specialized plastic-degrading strains) were added to three sustainable carriers (vermicompost, biochar, and calcium alginate beads) for the preparation of microbial formulations.

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Ruxolitinib has been approved for the treatment of adults and pediatric patients ≥12 years with steroid refractory graft-versus-host disease (GvHD). However, real-life studies are needed to confirm the results of clinical trials and further assess its efficacy in special populations. We performed a descriptive, retrospective, multi-center study of 352 adults and 42 pediatric patients treated with ruxolitinib for steroid-refractory acute or chronic GvHD.

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The accumulation of plastic in ecosystems is one of the most critical environmental concerns today. Plastic biodegradation using individual microbial cultures has shown limited success, which can be improved by employing microbial consortia with appropriate enzymatic capabilities. This study aims to assemble and characterize microbial consortia using ligninolytic fungi and bacteria isolated from an agricultural waste composting process, with the goal of enhancing the efficiency of plastic biodegradation.

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Background: Allogeneic haematopoietic stem-cell transplantation (allo-HSCT) markedly reduces HIV reservoirs, but the mechanisms by which this occurs are only partly understood. In this study, we aimed to describe the dynamics of virological and immunological markers of HIV persistence after allo-HSCT.

Methods: In this prospective observational cohort study, we analysed the viral reservoir and serological dynamics in IciStem cohort participants with HIV who had undergone allo-HSCT and were receiving antiretroviral therapy, ten of whom had received cells from donors with the CCR5Δ32 mutation.

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Article Synopsis
  • A study compared the effectiveness of posttransplant cyclophosphamide (PTCy) versus conventional calcineurin inhibitor (CNI)-based regimens for preventing graft-versus-host disease (GVHD) in patients with Hodgkin lymphoma undergoing hematopoietic stem cell transplantation (HSCT) from HLA-matched donors.
  • Results showed that while PTCy was linked to slower recovery of blood cells, it significantly reduced the risk of chronic GVHD and improved long-term survival measures, including overall survival (OS) and progression-free survival (PFS).
  • Overall, PTCy exhibited better outcomes in reducing relapse rates and improving survival compared to CNI-based prophylaxis in this patient group, suggesting it may be a
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