Publications by authors named "M Juonala"
Context: Exogenous insulin is reported to have both vasodilatory and vasoconstrictive effects on the microvasculature. Little is known about the associations of long-term endogenous insulin exposure with microvasculature.
Objective: To test the hypothesis that long-term exposure to high insulin levels in childhood and adulthood is associated with adverse changes in retinal microvasculature in adulthood in a population without diabetes.
Article Synopsis
- The study examines the relationship between socioeconomic disadvantage and body mass index (BMI) among children and adults while considering genetic predisposition to obesity.
- By analyzing data from a sizable population-based cohort, the researchers found that children with higher polygenic risk for obesity are more affected by socioeconomic disadvantage.
- Hypothetical interventions to reduce this disadvantage could significantly lower rates of adolescent overweight/obesity, especially among those with high genetic risk, suggesting that addressing childhood disadvantage may be an effective strategy for obesity prevention.
In recent years, there has been a notably increased interest in the study of multivariate interactions and emergent higher-order dependencies. This is particularly evident in the context of identifying synergistic sets, which are defined as combinations of elements whose joint interactions result in the emergence of information that is not present in any individual subset of those elements. The scalability of frameworks such as partial information decomposition (PID) and those based on multivariate extensions of mutual information, such as O-information, is limited by combinational explosion in the number of sets that must be assessed.
View Article and Find Full Text PDFImportance: Despite its relevance for pediatric blood pressure (BP) screening, the long-term predictive utility and natural progression of pediatric BP classification remain understudied.
Objective: To evaluate BP tracking from childhood to midadulthood using the American Academy of Pediatrics (AAP) thresholds and estimate transition probabilities among BP classifications over time considering multiple time points.
Design, Setting, And Participants: The analyses were performed in 2023 using data gathered from September 1980 to August 2018 within the longitudinal Cardiovascular Risk in Young Finns Study.