Contribution to some radiobiological aspects of the investigation of chemical radiosensitizers of hypoxic cells. Part V: Metronidazole--dependence of its radiosensitizing effect on the dose, time interval of administration and hypoxia degree of the bone marrow evaluated according to the changes of its cellularity in rats.

In the experiments on female rats of Wistar strain the effect of metronidazole (Entizol - Polfa) was studied administrated in aqueous solution with a gastric pipette into the stomach. Dependence was analyzed on the dose of metronidazole, on the time interval of administration before irradiation and on the degree of hypoxia of bone marrow during irradiation induced in the lower part of the body and graded by the abdomen compression with an inflatable rubber cuff with overpressure 4, 6.7, 13.

Contribution to some radiobiological aspects of the investigation of radiosensitizers of hypoxic cells. Part IV: Radiosensitizing effect of metronidazole evaluated on the level of postirradiation changes of bone marrow cellularity in rats protected by induced hypoxia of lower body half.

Radiosensitizing effect of metronidazole (Entizol, Polfa, Poland) was tested on an experimental model of ischaemized bone marrow. The changes of bone marrow cellularity were recorded after whole body irradiation of rats protected with abdomen compression during irradiation. With an increasing dose of irradiation proportional and significant decrease of nuclear elements in bone marrow occurred the third day after irradiation.