Publications by authors named "M Jose Perez Saez"
While acute myocardial infarction is rare in children, a part of the pediatric population is at a higher risk due to preexisting non-modifiable conditions. To mitigate the risk, modifiable risk factors such as unhealthy diet or sedentary lifestyle should be controlled from childhood, promoting healthy habits from the earliest stages. The primary purpose of this review is to assess the evidence on lifestyle/nutrition related modifiable risk factor intervention on the risk of acute myocardial infarction in children found in four databases, PubMed, Embase, Scopus and WoS.
View Article and Find Full Text PDFStructural changes of chromatin modulate access to DNA for the molecular machinery involved in the control of transcription. These changes are linked to variations in epigenetic marks that allow to classify chromatin in different functional states depending on the pattern of these histone marks. Importantly, alterations in chromatin states are known to be linked with various diseases, and their changes are known to explain processes such as cellular proliferation.
View Article and Find Full Text PDFMetastatic melanoma is an aggressive and deadly form of skin cancer, known for its rapid ability to spread to other organs. Melanoma metastasis involves several steps: Local invasion, lymphovascular invasion and proliferation to new sites. This process is facilitated by genetic alterations, interactions with the tumor microenvironment and evasion of the immune system.
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- - Penile cancer is a rare type of tumor, more frequently seen in low- and middle-income countries, with major risk factors being age, ethnicity, smoking, hygiene, and HPV infection.
- - Early detection can lead to high cure rates (up to 80%), but late diagnosis significantly lowers survival chances, especially when the cancer has spread.
- - The study assesses various biomarkers related to cell growth, inflammation, and other processes in penile squamous cell carcinoma, suggesting that the degree of cell differentiation affects these biomarkers' expression, which may help in predicting disease outcomes.
In the face of cell damage, cells can initiate a response ranging from survival to death, the balance being crucial for tissue homeostasis and overall health. Cell death, in both accidental and regulated forms, plays a fundamental role in maintaining tissue homeostasis. Among the regulated mechanisms of cell death, ferroptosis has garnered attention for its iron-dependent phospholipid (PL) peroxidation and its implications in aging and age-related disorders, as well as for its therapeutic relevance.
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