Publications by authors named "M Jose Lopez-Andreo"
Maternal dietary fat intake during pregnancy and lactation may influence the bioavailability of essential lipophilic nutrients, such as docosahexaenoic acid (DHA), that are important for both the mother and her child's development. This study aimed to evaluate the effects of different maternal fat diets on fat absorption and pup brain development by analyzing gene expression. Rats were fed diets with different lipid matrices during pregnancy and lactation: diet A, mono and diglycerides (MDG) + soy lecithin phospholipids (PL); diet B, MDG + soy lecithin PL + milk-derived PL; and a control diet.
View Article and Find Full Text PDFBackground: In a previous study, the 84-day administration of glycosaminoglycans (GAGs), with or without native collagen type II (NC), in an osteoarthritis (OA)-induced rabbit model slowed down OA progression, improved several micro- and macroscopic parameters and magnetic resonance imaging (MRI) biomarkers in cartilage, and increased hyaluronic acid levels in synovial fluid. To elucidate the potential underlying mechanisms, a transcriptomics approach was conducted using medial femoral condyle and trochlea samples.
Results: The administration of chondroitin sulfate (CS), glucosamine hydrochloride (GlHCl), and hyaluronic acid (HA), with (CGH-NC) or without (CGH) NC, strongly modulated several genes involved in chondrocyte extracellular matrix (ECM) remodeling and homeostasis when compared to non-treated rabbits (CTR group).
Article Synopsis
- The study investigates how specific immune cell types in blood samples from patients with metastatic castration-resistant prostate cancer (mCRPC) can affect survival rates.
- Researchers analyzed pre-treatment blood samples from 152 patients and found that lower CD8 T-cell counts and higher monocyte levels were linked to shorter survival.
- Their results suggest that these immune cell types could act as important biomarkers for mCRPC management, supporting the need for further research in clinical trials.
Whole Sequencing and Detailed Analysis of SARS-CoV-2 Genomes in Southeast Spain: Identification of Recurrent Mutations in the 20E (EU1) Variant with Some Clinical Implications.
Diseases
March 2023
Article Synopsis
- The study analyzes 88 SARS-CoV-2 genomes from COVID-19 patients at "Reina Sofía" Hospital in Spain between October 2020 and April 2021 to track emerging variants and mutations.
- It notes that the 20E (EU1) variant was predominant at 71.6%, while the Alpha variant was rising at 14.8%, with concerning mutations found in the spike protein of some 20E genomes.
- Statistical analysis indicates a significant correlation between the age of patients and the severity of COVID-19 symptoms, particularly in samples with more genetic mutations.
Background: Germline mutations in RUNX1 can cause a familial platelet disorder that may lead to acute myeloid leukemia, an autosomal dominant disorder characterized by moderate thrombocytopenia, platelet dysfunction, and a high risk of developing acute myeloid leukemia or myelodysplastic syndrome. Discerning the pathogenicity of novel RUNX1 variants is critical for patient management.
Objectives: To extend the characterization of RUNX1 variants and evaluate their effects by transcriptome analysis.