Publications by authors named "M Jose Carmena"
Article Synopsis
- The study investigates the combined effects of GHRH-R antagonist MIA-690 and EGFR inhibitor Gefitinib on advanced prostate cancer cells, as treating castration-resistant prostate cancer (CRPC) is challenging due to drug resistance.
- Findings show that this combination therapy significantly reduces cell viability, adhesion, and metalloprotease activity, while also causing cell cycle arrest in prostate cancer PC-3 cells.
- In vivo results from athymic nude mice confirm that the combined treatment is more effective against tumors than using either drug alone, by disrupting the interaction between GHRH-R and EGFR pathways.
Article Synopsis
- Heart transplant recipients (HTr) are at greater risk for severe COVID-19, and a study analyzed their prognosis over the pandemic from February 2020 to October 2022.* -
- Among 308 HTr studied, 39.2% were infected; those with pneumonia had significantly worse outcomes, with higher hospitalization and death rates compared to less severe cases.* -
- Improvements in prognosis were noted over time, with reduced pneumonia (from 62% to 19%) and mortality (from 23% to 4%), attributed to factors like vaccination and early remdesivir treatment.*
Study Aim: To investigate the efficacy of PD-1-directed antibody-based therapy in patients with symptomatic melanoma brain metastases (MBM) and concurrent treatment with corticosteroids.
Methods: This retrospective cohort study included patients with cutaneous melanoma with symptomatic MBM and concurrent treatment with corticosteroids who received PD-1-directed antibody-based treatment at the Royal Marsden Hospital London between 2016 and 2021. The primary outcome was overall survival (OS), secondary outcomes were intracranial response rate (ORR) and duration of response (DOR).
Carbosilane dendrimers are hyperbranched lipophilic scaffolds widely explored in biomedical applications. This work exploits, for the first time, the ability of these scaffolds to generate functional hydrogels with amphiphilic properties. The monodispersity and multivalency enable a precise synthetic control of the network, while the lipophilicity improves the compatibility with poorly soluble cargo.
View Article and Find Full Text PDF