Publications by authors named "M Jorjani"
Aims: Post stroke hyperglycemia has been shown to deter functional recovery. Earlier findings have indicated the cap-dependent translation regulator 4E-BP1 is detrimentally upregulated in hyperglycemic conditions. The present study aims to test the hypothesis that hyperglycemic ischemic reperfusion injury (I/R) affects normal protein translation poststroke.
View Article and Find Full Text PDFObjectives: Most individuals who suffer from spinal cord injury (SCI) experience neuropathic pain, which currently has no effective treatment. In this study, we examined how testosterone affects neuropathic pain resulting from SCI.
Materials And Methods: We administered three different doses of testosterone (4, 8, 16 mg/kg, intraperitoneal) to male rats after an electrolytic lesion of the spinothalamic tract.
Article Synopsis
- The article presents the first national guidelines for managing acute coronary syndrome (ACS) in Iran, detailing diagnosis, treatment, and secondary prevention strategies.
- A group of specialists examined clinical concerns and formulated 13 key questions, leading to recommendations based on systematic evidence review.
- The guidelines include initial response protocols for chest pain, risk categorization for patients, treatment options in hospitals, and strategies for secondary prevention post-ACS.
Spinal cord injury (SCI) is a common neurological disease worldwide, often resulting in a substantial decrease in quality of life, disability, and in severe cases, even death. Unfortunately, there is currently no effective treatment for this disease. Nevertheless, current basic and clinical evidence suggests that vitamins, with their antioxidant properties and biological functions, may play a valuable role in improving the quality of life for individuals with SCI.
View Article and Find Full Text PDFArticle Synopsis
- This guideline is Iran's first systematic approach for diagnosing and managing hyperlipidemia in adults, addressing key clinical questions with evidence-based recommendations.
- It sets specific thresholds for LDL-C (over 190 mg/dL) and triglycerides (over 500 mg/dL) to initiate drug treatment while emphasizing lifestyle changes as the primary intervention.
- Statins are recommended as the first-line medication, with additional options proposed for high levels, and targets for LDL-C (<130 mg/dL) and triglycerides (<200 mg/dL) are specified for adults without comorbidities.