Publications by authors named "M Jorissen"
Article Synopsis
- The study aimed to explore the relationship between clinical features and pathogenic gene variants in patients with Primary Ciliary Dyskinesia (PCD).
- Conducted at the University Hospitals Leuven, it included 74 patients with genetically confirmed PCD, focusing on common genes like DNAH11 and DNAH5, and analyzing their genotype, ultrastructural data, and clinical characteristics.
- Findings indicated that certain clinical features differed significantly between patients with DNAH11 and DNAH5 variants, but other factors like lung function and microbiology did not show significant differences, suggesting some correlations exist in clinical characteristics based on genotypes.
Background: The introduction of CFTR modulators has changed the landscape in the treatment of cystic fibrosis (CF) and early case series have shown improvements in sinonasal outcomes in this patient population.
Methodology: A real-word data study was performed to evaluate the impact of dual therapy with tezacaftor/ivacaftor (TEZ/IVA) and triple therapy with elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) on CF-related chronic rhinosinusitis (CRS), by comparing subjective and objective outcome measures at baseline, 12 months after treatment with TEZ/IVA and six months after treatment with ELX/TEZ/IVA.
Results: In total, 43 CF patients, with a mean age of 32 years, were included.
Article Synopsis
- Nasal hyperreactivity (NHR) is common in chronic upper airway conditions like allergic rhinitis and chronic rhinosinusitis with nasal polyps, primarily driven by type 2 inflammation.
- In a study involving 18 healthy controls and 45 patients, cold dry air provocation tests showed that NHR significantly reduced nasal airflow in patients, correlating subjective experiences with objective measurements.
- Findings suggest that NHR varies in severity and is influenced by factors like neurogenic inflammation and increased histamine levels, indicating a spectrum of reactivity rather than a simple presence or absence.
We present a protocol for the rapid postmortem bedside procurement of selected tissue samples using an endoscopic endonasal surgical technique that we adapted from skull base surgery. We describe steps for the postmortem collection of blood, cerebrospinal fluid, a nasopharyngeal swab, and tissue samples; the clean-up procedure; and the initial processing and storage of the samples. This protocol was validated with tissue samples procured postmortem from COVID-19 patients and can be applied in another emerging infectious disease.
View Article and Find Full Text PDFBackground: The skin prick test (SPT) is the gold standard for identifying allergic sensitization in individuals suspected of having an inhalant allergy. Recently, it was demonstrated that SPT using a novel skin prick automated test (SPAT) device showed increased reproducibility and tolerability compared to the conventional SPT, among other benefits.
Objective: This study aimed to evaluate prick location bias using the novel SPAT device.