Publications by authors named "M Jonsbu"

Background: The use of sulphonylureas for type 2 diabetes has been debated since 1970, when the University Group Diabetes Program (UGDP) reported increased cardiovascular mortality with tolbutamide treatment.

Material And Methods: We try to present a balanced review of the current knowledge of the possible cardiovascular side effects of sulphonylureas.

Results: Recent studies on the molecular actions of sulphonylureas show that sulphonylureas, in addition to closing K+ ATP channels in insulin producing cells, also do so in the myocard and in vascular smooth muscle.

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