Publications by authors named "M Joncquel"
Article Synopsis
- The study investigates the effectiveness of a rapid immunoassay technique (Snibe) versus mass spectrometry (LC-MS/MS) in measuring plasma homocysteine levels, particularly in patients with nitrous oxide abuse.
- Significant elevations in plasma homocysteine were found in nitrous oxide abusers, with the immunoassay delivering faster results, although it generally underestimated high levels compared to LC-MS/MS.
- The findings highlight the need for the immunoassay as a quick initial screening tool, while still recommending confirmation with LC-MS/MS for accurate diagnosis of conditions associated with oxidative stress.
Tacrolimus (FK506) is an immunosuppressant that is experiencing a continuous rise in usage worldwide. The related side effects are known to be globally dose-dependent. Despite numerous studies on FK506, the mechanisms underlying FK506 toxicity are still not well understood.
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- Recreational use of nitrous oxide (NO) can lead to serious neurological and psychological disorders, prompting the need for reliable biological markers to diagnose abuse.
- The study analyzed data from 52 chronic NO abusers to evaluate the effectiveness of total vitamin B12, homocysteine, and methylmalonic acid (MMA) in correlating with NO consumption and clinical outcomes.
- While no specific marker was found for the level of NO consumption, elevated homocysteine levels indicated recent use, and MMA showed a stronger correlation with the severity of clinical symptoms.
In the last few years, there has been an increase in the recreational use of nitrous oxide (N2O), which can lead to neurological symptoms such as sensory or motor disorders. The literature links these symptoms to a functional inactivation of vitamin B12 by oxidation of its cobalt ion, which prevents the vitamin B12 from acting as a cofactor for methionine synthase. Thus, demyelination related to methionine deficiency could be responsible for the neurological disorders associated with N2O consumption, including the combined sclerosis of the spinal cord.
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