In vitro antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from Pappea capensis EckI & Zeyh. (Sapindaceae).

Ethnopharmacological Relevance: The Vha-Venda people of South Africa use Pappea capensis EckI & Zeyh. (Sapindaceae) twigs to treat malaria and its related symptoms.

Aim Of Study: The main aim of this study was to evaluate the antiplasmodial and cytotoxic activity of P.

H NMR-based metabolomics of antimalarial plant species traditionally used by Vha-Venda people in Limpopo Province, South Africa and isolation of antiplasmodial compounds.

Ethnopharmacological Relevance: The Vha-Venda people living in rural areas of Limpopo Province of South Africa regularly use traditional plant-based medicines to treat malaria. In our earlier publication, twenty indigenous plant species used to treat malaria or its symptoms by Vha-Venda people were evaluated for antiplasmodial activity. The main objective of the current study was to assess the robustness of NMR-based metabolomics in discriminating classes of secondary compounds that are responsible for the observed antimalarial activity and the isolation of antiplasmodial compounds.

In vitro antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria.

Ethnopharmacological Relevance: Plant species used by Venda people of South Africa in the treatment of malaria and associated symptoms were evaluated for their antiplasmodial efficacy as well as cytotoxic properties and some showed significant activity.

Materials And Methods: In vitro antiplasmodial activity and cytotoxic properties were evaluated on 20 indigenous plant species. Ground plant material was extracted in dichloromethane: 50% methanol (1:1).