Publications by authors named "M Joao Marta"
Article Synopsis
- Eccentric exercises can lead to muscle damage and inflammation, but curcumin, especially when stabilized, may help reduce these effects for athletes.
- This systematic review evaluates existing research on curcumin's effectiveness in minimizing muscle damage from sports activities.
- A total of 11 studies were analyzed, showing that curcumin supplementation may alleviate symptoms like pain and improve recovery after eccentric exercise.
The HLA profile is essential in cell and tissue transplantation, particularly in patients with autoimmune conditions and infections. Due to the extreme polymorphism in certain HLA loci, it also serves as a key tool for population genetic analysis. This study aimed to identify the allele and haplotype distributions of HLA class I (A, B, and C) and class II (DRB1) genotypes in unrelated hematopoietic stem cell donors.
View Article and Find Full Text PDFRecent studies demonstrate the efficacy of B cell-targeting therapies in managing multiple sclerosis (MS) activity, emphasizing the critical role of B cells in MS pathogenesis. CladB study aimed to quantify the temporal changes in peripheral immune cells and their activity over 96 weeks of Cladribine tablets (CladT) treatment in relapsing-remitting MS (RRMS). Ten participants (3 males, 7 females) had blood samples collected at multiple intervals (Day 0, 1, 5, then weekly for 8 weeks, biweekly for up to 24 weeks, and monthly for up to 96 weeks) for immune cell analysis, compared to a historical alemtuzumab-treated cohort.
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- The study investigates the potential role of specific variants of human leukocyte antigens (HLA) and microRNAs (miRNAs) in determining risk for mild cognitive impairment (MCI) and Alzheimer's disease (AD).
- A systematic review and meta-analysis were performed using international databases to assess how these genetic factors contribute to cognitive decline and their potential as early biomarkers for AD.
- Results indicated that certain HLA variants are linked to increased risk for cognitive decline while others provide protection, with let-7 and miR-15/16 identified as promising miRNA biomarkers for early detection of AD.
Aggressive Prolactinoma with Progression to Pituitary Carcinoma: A Case Report.
Endocr Metab Immune Disord Drug Targets
July 2024
Adenomas of the pituitary gland, predominantly prolactinomas, can exhibit aggressive behavior. Aggressive prolactinomas are characterized by radiographic invasion, rapid growth, clinically significant progression despite standard therapies, and recurrence after surgery or radiotherapy. Pituitary carcinoma is rare (0.
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