Publications by authors named "M Jesus Cancelo"
Chronic venous disease (CVD) comprises a spectrum of morphofunctional disorders affecting the venous system, affecting approximately 1 in 3 women during gestation. Emerging evidence highlights diverse maternofetal implications stemming from CVD, particularly impacting the placenta. While systemic inflammation has been associated with pregnancy-related CVD, preliminary findings suggest a potential link between this condition and exacerbated inflammation in the placental tissue.
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- Pre-eclampsia is a serious pregnancy condition marked by high blood pressure and protein in urine, with early-onset (EO-PE) and late-onset (LO-PE) classifications; LO-PE is more common but generally less severe.
- Previous studies indicated that inflammation in the placenta could contribute to pre-eclampsia, with hints that inflammasome hyperactivation might affect immune responses in affected women.
- This study analyzed gene and protein levels of inflammasome components in placentas from women with LO-PE, finding significant increases that suggest NLRP3 inflammasome involvement in the condition, highlighting the need for further research on this area.
Objectives: The objective is to assess the perception of gynecologists regarding patients' adherence to vulvovaginal atrophy (VVA) treatments, to evaluate the gynecologists' opinions on what their patients think about treatment adherence, and to compare the gynecologists' opinions with the patients' own perceptions within the CRETA study.
Methods: Spanish gynecologists who participated in the CRETA study were asked to fill out an online 41-item questionnaire to evaluate their views on VVA management.
Results: From 29 centers across Spain, 44 gynecologists completed the survey.
Increased life expectancy means that women are now in a hypoestrogenic state for approximately one-third of their lives. Overall health and specifically bone health during this period evolves in accordance with aging and successive exposure to various risk factors. In this review, we provide a summary of the approaches to the sequential management of osteoporosis within an integrative model of care to offer physicians a useful tool to facilitate therapeutic decision-making.
View Article and Find Full Text PDFObjective: To assess the correlation of different vulvovaginal atrophy therapeutic options with the quality of life of postmenopausal women.
Study Design: The CRETA study is a descriptive, observational, cross-sectional, multicenter study designed to measure, besides treatment satisfaction and adherence, the quality of life of postmenopausal women diagnosed with vulvovaginal atrophy in 29 hospitals and centers across Spain.
Main Outcome Measures: The study enrolled postmenopausal women currently receiving treatment with vaginal moisturizers, local estrogen therapy or ospemifene.