Publications by authors named "M Jerkic"
Mesenchymal stromal cells (MSCs) are multipotent, non-hematopoietic cells that have the ability to differentiate into several mature cell types, including adipocytes, chondrocytes, osteoblasts, and myoblasts [...
View Article and Find Full Text PDFDue to their beneficial effects in an array of diseases, Mesenchymal Stromal Cells (MSCs) have been the focus of intense preclinical research and clinical implementation for decades. MSCs have multilineage differentiation capacity, support hematopoiesis, secrete pro-regenerative factors and exert immunoregulatory functions promoting homeostasis and the resolution of injury/inflammation. The main effects of MSCs include modulation of immune cells (macrophages, neutrophils, and lymphocytes), secretion of antimicrobial peptides, and transfer of mitochondria (Mt) to injured cells.
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- COVID-19 has caused higher death rates in men than women despite similar infection rates, prompting research into the biological reasons behind this disparity.
- Researchers found that female mice had a unique protein expression profile in their lungs, leading to better protection against severe infections due to increased ACE2 expression and a favorable balance of estrogen and androgen receptors.
- The study suggests that inhaling recombinant ACE2 may help protect male mice from severe infections by acting as a decoy for the virus and also shows promise for treating human lung organoids infected with the Delta variant.
Article Synopsis
- The study investigates how remote ischemic preconditioning (RIPC) can protect the liver from injury caused by hemorrhagic shock-resuscitation (HSR) in mice, focusing on the role of parkin-dependent mitophagy.
- RIPC effectively reduced liver damage in wild type mice after HSR, but this protective effect was absent in mice lacking the parkin gene, indicating the importance of parkin in this process.
- The findings suggest that enhancing mitophagy may offer new therapeutic strategies for conditions related to ischemia-reperfusion injury.
Lung macrophages (Mφs) are essential for pulmonary innate immunity and host defense due to their dynamic polarization and phenotype shifts. Mesenchymal stromal cells (MSCs) have secretory, immunomodulatory, and tissue-reparative properties and have shown promise in acute and chronic inflammatory lung diseases and in COVID-19. Many beneficial effects of MSCs are mediated through their interaction with resident alveolar and pulmonary interstitial Mφs.
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