Bacterial bioburden of wounds: influence of debridement and negative-pressure wound therapy (NPWT).

Objective: To clarify the role of microbiological swabs in surgical decision-making, we investigated the effect of negative-pressure wound therapy (NPWT) and serial surgical debridement on bacterial bioburden in hard-to-heal wounds and ultimately correlated them with the success of surgical closure.

Method: All patients were treated with surgical debridement, jet lavage and NPWT before their wounds were finally closed. The treatment effect was assessed by correlating microbiological swabs obtained immediately after intervention with those obtained after removal of the dressings during the following surgical procedures.

Use of Oral Anticoagulation and Diabetes Do Not Inhibit the Angiogenic Potential of Hypoxia Preconditioned Blood-Derived Secretomes.

Patients suffering from tissue ischemia, who would greatly benefit from angiogenesis-promoting therapies such as hypoxia preconditioned blood-derived secretomes commonly receive oral anticoagulation (OA) and/or have diabetes mellitus (DM). In this study, we investigated the effect of OA administration on the in vitro angiogenic potential of hypoxia preconditioned plasma (HPP) and serum (HPS), prepared from nondiabetic/diabetic subjects who did not receive OA ( = 5) or were treated with acetylsalicylic acid (ASA, = 8), ASA + clopidogrel ( = 10), or nonvitamin K antagonist oral anticoagulants ( = 7) for longer than six months. The effect of DM was differentially assessed by comparing HPP/HPS obtained from nondiabetic ( = 8) and diabetic ( = 16) subjects who had not received OA in the past six months.

[Appropriate procedure with suspected intoxicated drivers--a discussion of recent theories on diagnosis and rehabilitation].

Within the last couple of years a dramatic change of judging the drinking driver has taken place having serious consequences for the individuals involved. Many DWI offenders are forced to abstain from any alcoholic beverage though characteristics of personality as well as of offence indicate that rehabilitation by participation in an intervention program may result in the same reduction of relapse probability as for a comparable group of drivers in the years before. The changed reflection is mainly caused by a superficial overestimation of blood alcohol concentration (BAC) figures found at the time of event.

[Remedial courses for alcohol apprehended drivers are effective!].

The effectiveness of the IFT, I.R.A.