Publications by authors named "M Jargosch"
Lichen planus (LP) is a chronic inflammatory disease (ISD) affecting skin, mucosa, nail, and hair. Previous studies demonstrated a pivotal role of type 1 immunity in LP, as infiltrating T cells trigger apoptosis and necroptosis in the epidermis. In this study, we investigated the role of DAPK1 in LP with special focus on its role in mediating cell death and inflammation.
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- Atopic dermatitis (AD) is a common chronic skin condition, and new treatments are emerging, including biologics targeting specific immune responses and Janus kinase inhibitors that have a broader impact on cytokines.
- This study categorizes AD patients into three groups based on their levels of IFNG expression, revealing differences in disease characteristics and immune responses between groups with high and low IFNG levels.
- The findings suggest that these IFNG subgroups reflect intrinsic and extrinsic types of AD and may help in tailoring treatments and identifying patients who may not respond to current therapies.
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- Sebaceous glands play a key role in acne, but their impact on other skin diseases like psoriasis and atopic dermatitis is still not fully understood.
- A study examined sebaceous glands' gene expression in human skin samples from patients with these conditions, finding distinct patterns related to lipid metabolism and inflammation.
- The results indicate that sebaceous glands actively influence inflammation in skin diseases and contribute to skin health differently depending on the condition.
Background: Darier's disease (DD) is a genodermatosis caused by mutations of the ATP2A2 gene leading to disrupted keratinocyte adhesion. Recurrent episodes of skin inflammation and infections with a typical malodour in DD indicate a role for microbial dysbiosis. Here, for the first time, we investigated the DD skin microbiome using a metabarcoding approach of 115 skin swabs from 14 patients and 14 healthy volunteers.
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