Publications by authors named "M Jankovic"
Article Synopsis
- Variants associated with neurodevelopmental impairments in children are complex and challenging to evaluate due to their diverse nature and unclear causes.
- The study highlights a case of a child with neonatal-onset epilepsy and a specific genetic variant (G256W) that impacts ion channel function and leads to reduced cell stability and conduction in nervous tissue.
- The research also establishes a mouse model that exhibits epilepsy and hyperexcitability in brain cells, linking the genetic variant to observable neurological behaviors and suggesting potential wider implications for understanding similar conditions in other patients.
Article Synopsis
- Research focused on thermal decomposition (pyrolysis) of coal bottom ash from a Serbian power plant, revealing its composition and thermal behavior through TG-DTG and XRD analyses.
- The study unveiled complex reaction mechanisms, including endothermic dissociation reactions and autocatalytic processes involving chromium for enhanced ethylene polymerization.
- Results indicated that the thermal treatment improved the physicochemical properties of the ash and showcased its high thermal stability, suggesting potential for safer, environmentally friendly applications.
West Nile Virus (WNV) is considered one of the most widely distributed arboviruses worldwide. In 2018, Serbia was among the European countries reporting the highest number of WNV cases. This study aimed to characterize WNV strains circulating in Serbia, and to estimate the pathways and dynamics of WNV-2 spread in the Balkans and globally through the phylogenetic approach.
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- Exome sequencing (ES) can reveal secondary findings unrelated to the primary reason for testing, which may benefit patient care.
- In this study, researchers analyzed 81 relevant genes in 443 patients with neurological disorders and identified 17 variants in 9 genes categorized into cancer, cardiovascular, and miscellaneous phenotypes.
- Most of the variants were classified as either known pathogenic or expected pathogenic, suggesting that these findings could help prevent serious health issues and enhance understanding of genetic factors in the Serbian population.
Background/objectives: Degenerative cerebellar ataxias (DCA) present a group of complex neurological disorders primarily affecting the cerebellum and its pathways. Classic manifestations include motor symptoms of cerebellar ataxia. However, emerging evidence suggests that the cerebellum also plays a crucial role in various cognitive and emotional processes.
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