Publications by authors named "M Jakubczyk"
Background: Clinical trials handle a huge amount of data which can be used during the trial to improve the ongoing study conduct. It is suggested by regulators to implement the remote approach to evaluate clinical trials by analysing collected data. Central statistical monitoring helps to achieve that by employing quantitative methods, the results of which are a basis for decision-making on quality issues.
View Article and Find Full Text PDFThe present study describes the data sets produced in Warsaw, Poland with the aim of developing tools and methods for the implementation of human-centred and data-driven solutions to the enhancement of sustainable mobility transition. This study focuses on school commutes and alternatives to private cars for children drop off and pick up from primary schools. The dataset enables the complex analysis of interactions between determinants of transport mode choice, revealed choices, and air quality impact.
View Article and Find Full Text PDFArticle Synopsis
- - Mitral regurgitation (MR) is the second most common heart valve disease, and severe cases often require surgical intervention, though high-risk patients may need alternative treatments like transcatheter edge-to-edge valve repair or the Tendyne valve.
- - The Tendyne valve, which can be implanted without traditional surgery, showed promising results: 93.2% of patients had no MR after treatment, and heart failure hospitalizations significantly decreased post-surgery.
- - An economic analysis indicated that using the Tendyne valve is cost-effective compared to medications, with a favorable cost per quality-adjusted life year, and around 60 patients annually could benefit from this treatment in Poland.
Objectives: Human papillomavirus (HPV) is a prevalent sexually transmitted infection with significant implications for public health. In Poland, a nationwide vaccination program offers a choice between the 9-valent (9v) and 2-valent (2v) HPV vaccines. We aimed to assess the cost-effectiveness of the 9v vs 2v vaccine from the public payer perspective in Poland.
View Article and Find Full Text PDFActivation of phenols by a Ru-catalyst allows for the resulting η-phenoxo complex to selectively react with a variety of nucleophiles under mechanochemical conditions. Conversion of phenolic hydroxy groups without derivatization is important for late-stage modifications of pharmaceuticals and in the context of lignin-material processing. We present a one-step, Ru-catalyzed cross-coupling of phenols with boronic acids, aryl trialkoxysilanes and potassium benzoyltrifluoroborates under mechano-chemical conditions.
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