Publications by authors named "M Jagodic"
Background: Inter-individual differences in treatment response are marked in multiple sclerosis (MS). This is true for Natalizumab (NTZ), to which a subset of patients displays sub-optimal treatment response. We conducted a multi-centric genome-wide association study (GWAS), with additional pathway and network analysis to identify genetic predictors of response to NTZ.
View Article and Find Full Text PDFMultiple Sclerosis (MS) is a heterogeneous inflammatory and neurodegenerative disease with an unpredictable course towards progressive disability. Treating progressive MS is challenging due to limited insights into the underlying mechanisms. We examined the molecular changes associated with primary progressive MS (PPMS) using a cross-tissue (blood and post-mortem brain) and multilayered data (genetic, epigenetic, transcriptomic) from independent cohorts.
View Article and Find Full Text PDFArticle Synopsis
- Aging impacts all cell types in the central nervous system (CNS) and is linked to disorders like Multiple Sclerosis, with notable changes in myelin structure.
- Directly converted oligodendrocytes (dchiOL) from donors of differing ages showed reduced maturation in older individuals, alongside increased oxidative stress and markers of cellular aging.
- Transcriptomic analysis revealed substantial gene expression changes with age, and epigenetic studies identified a specific age-related signature, indicating that both normal aging and conditions like Multiple Sclerosis accelerate epigenetic aging.
Article Synopsis
- Central nervous system (CNS) cells, like microglia and astrocytes, play critical roles in the development and progression of multiple sclerosis (MS) through their inflammatory responses.
- Recent findings show that these cells not only promote inflammation but can also help resolve it, highlighting their complexity and protective functions.
- Heparin-binding EGF-like growth factor (HB-EGF) is identified as a key player in providing anti-inflammatory and protective effects during MS, with potential therapeutic implications, especially when administered intranasally in preclinical studies.