Publications by authors named "M Jaffrelot"
Article Synopsis
- Sarcomas are not typically associated with Lynch Syndrome (LS), but recent literature suggests a connection, prompting a national study to investigate their characteristics in LS patients.
- The SarcLynch study included 81 patients, finding that 83% had soft-tissue sarcomas, particularly pleomorphic variants like undifferentiated pleomorphic sarcoma and pleomorphic rhabdomyosarcoma, with 40% having sarcoma as their first cancer event.
- Results showed a high prevalence of mismatch repair deficiency and promising responses to immune checkpoint inhibitors, suggesting the need for screening and potential immunotherapy for these sarcomas.
Article Synopsis
- - Pralsetinib, a selective RET tyrosine kinase inhibitor, showed effectiveness and tolerability in treating lung and thyroid cancers linked to specific gene mutations and fusions during clinical trials.
- - A case report detailed a 53-year-old patient with a neuroendocrine tumor who achieved partial response after five lines of therapy with pralsetinib but experienced multiple severe infections, including pneumonia and spondylodiscitis.
- - The study emphasizes the heightened risk of opportunistic infections associated with pralsetinib, likely due to its off-target effects on JAK1/2, unlike another comparable treatment called selpercatinib.
The 2024 French guidelines for scenario design in simulation-based education: manikin-based immersive simulation, simulated participant-based immersive simulation and procedural simulation.
Guillaume Der Sahakian Maxime de Varenne Clément Buléon Guillaume Alinier Christian Balmer Morgan Jaffrelot
Med Educ Online
December 2024
Article Synopsis
- Simulation-based education in healthcare utilizes realistic clinical scenarios for effective learning, and the SoFraSimS has created guidelines to enhance scenario design for various simulation types.
- A literature review and expert input led to the identification of key criteria for creating effective simulation scenarios across modalities.
- The resulting templates consist of five sections that structure scenario context, learning objectives, preparation needs, simulation analysis, and post-simulation improvements to maximize educational outcomes.*
Background: Although peer-assisted learning is known to be effective for reciprocal learning in medical education, it has been understudied in simulation. We aimed to assess the effectiveness of peer-led compared to instructor-led debriefing for non-technical skill development in simulated crisis scenarios.
Methods: Sixty-one undergraduate medical students were randomized into the control group (instructor-led debriefing) or an intervention group (peer debriefer or peer debriefee group).
Article Synopsis
- Lynch syndrome (LS) is linked to a higher risk of various tumors, including colorectal and non-colorectal cancers, with recent studies suggesting a potential association with sarcomas.
- A systematic review of 44 studies involving LS patients revealed that most sarcomas developed in individuals with a mutation in the MSH2 gene and showed distinct genetic features typical of LS-related tumors.
- Among the types of sarcomas observed, undifferentiated pleomorphic sarcoma, leiomyosarcoma, and liposarcoma were the most common, but there was also a notable occurrence of rhabdomyosarcoma, warranting further research to understand this specific group better.