Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution.

The ability to accurately quantify biological age could help monitor and control healthy aging. Epigenetic clocks have emerged as promising tools for estimating biological age, yet they have been developed from heterogeneous bulk tissues, and are thus composites of two aging processes, one reflecting the change of cell-type composition with age and another reflecting the aging of individual cell-types. There is thus a need to dissect and quantify these two components of epigenetic clocks, and to develop epigenetic clocks that can yield biological age estimates at cell-type resolution.

Effect of Medium Chain Triglycerides and Whey Protein Isolate Preloads on Glycaemia in Type 2 Diabetes: A randomised crossover study.

Background: Small nutritional preloads can reduce postprandial glucose excursions in individuals with and without metabolic syndrome or T2D. However, most studies have focused on preloads administered before single meals and have predominantly used protein-based preloads.

Objective: To investigate the effects of sequential consumption of medium chain triglycerides (MCT) and whey protein isolate (WPI) preloads before breakfast lunch and dinner on postprandial, diurnal and 24h glycaemia in individuals with T2D.

Perceiving Ethical Discomfort Triggered by Situations that Resist Meaning in Community Mental Health Settings: A Grounded Theory.

Community mental health care is a practice setting conducive to the emergence of special situations since the intervention takes place in the client's living environment, a context fraught with multiple and often unpredictable events and triggers. In addition, the healthcare workers are often alone in making decisions. This can lead to a persistent feeling of discomfort when the situation can be seen from several different angles and the healthcare workers find it difficult to make the right decision or are uncomfortable with the consequences of a decision they must make.