Time-dependent fear memory generalization triggered by phosphodiesterase 5 inhibition during reconsolidation.

Fear generalization, a lack of discrimination between safe and unsafe cues, is a hallmark of posttraumatic stress disorder. The phosphodiesterase 5 (PDE5) regulates the cyclic guanosine monophosphate (cGMP) pathway, which has been proposed to be involved in fear memory generalization. However, whether PDE5 activity underlies fear memory generalization remains unexplored.

The school environment in the experience of children with special health needs: a qualitative study.

Objective: To understand the experience of children with special health needs at school.

Method: Qualitative research using Symbolic Interactionism as a theoretical framework and assumptions of Grounded Theory as a methodological framework. Data collected in a pediatric outpatient clinic of a teaching hospital in an inland city of the state of São Paulo.

Autoantibody clusters in childhood-onset systemic lupus erythematosus: Insights from a multicenter study with 912 patients.

To identify clusters of autoantibodies in a large cSLE population and to verify possible associations between different autoantibody clusters and the following variables: demographic data, cumulative clinical and laboratory manifestations, disease activity, cumulative damage and mortality. A cross-sectional study was performed in 27 Pediatric Rheumatology University centers, including 912 cSLE patients. The frequencies of seven selected autoantibodies (anti-dsDNA, anti-Ro/SSA, anti-La/SSB, anti-Sm, anti-RNP, aCL IgM and/or IgG and LA) were used for cluster analysis using the K-means method.

Search for Healthcare and Breast/Gynecological Cancer Prevention Among Brazilian Lesbian Cisgender Women.

Although breast, cervical, endometrial, and ovarian cancers account for more than 43% of new cases in 2023 in Brazilian women, no national studies were found on the incidence, risk factors, and prevention of breast and gynecological neoplasms in lesbian women, causing the health needs of non-heterosexual women to go unnoticed by professionals. This study aims to identify and analyze the search for healthcare related to the prevention of breast/gynecological cancer among Brazilian lesbian cisgender women who have not had the disease. Seven lesbian women participated in this qualitative study.

Poor Oral Health-Related Quality of Life and Frailty Among PLWHIV: A Cross-Sectional Study.

Aims: This study aimed to explore the association between frailty and pre-frailty in people living with human immunodeficiency virus (PLWHIV), focusing on their oral health-related quality of life (OHRQoL) and health-related quality of life (HRQoL).

Materials And Methods: A cross-sectional study was conducted with 184 PLWHIV. Frailty status was assessed using Fried's frailty criteria, categorizing participants as robust, pre-frail, or frail.