Publications by authors named "M Jaakkola"
The percentage of obese people is increasing worldwide, causing versatile health problems. Obesity is connected to diseases such as diabetes and cardiovascular diseases, which are preceded by a state called metabolic syndrome. Diets rich in fruits and vegetables have been reported to decrease the risk of metabolic syndrome and type 2 diabetes.
View Article and Find Full Text PDFThe quality of sleep plays a significant role in determining human well-being, and studying sleep and sleep disorders using various methods can aid in the prevention and treatment of diseases. Positron emission tomography (PET) is a noninvasive and highly sensitive medical imaging technique that has been widely adopted in the clinic. This review article provides data on research activity related to sleep and sleep apnea and discusses the use of PET in investigating sleep apnea and other sleep disorders.
View Article and Find Full Text PDFArticle Synopsis
- Changes in land use and climate change are negatively impacting biodiversity, which may lead to increased prevalence of asthma and allergies due to insufficient immune regulation.
- The study performed a systematic review of 2,419 studies to explore how biodiversity, both inner (gut, skin, airways) and outer (environmental factors), relates to asthma and allergic conditions.
- Findings show that outer biodiversity may offer some protective effects against asthma and allergies, while the impact of inner biodiversity remains unclear, indicating a need for further research, particularly on outer biodiversity.
Background: There is inconsistent evidence of the effects of exposure to ambient air pollution on the occurrence of lower respiratory tract infections (LRTIs) in early childhood. We assessed the effects of individual-level prenatal and early life exposure to air pollutants on the risk of LRTIs in early life.
Methods: We studied 2568 members of the population-based Espoo Cohort Study born between 1984 and 1990 and living in 1991 in the City of Espoo, Finland.
Purpose: TILT-123 (igrelimogene litadenorepvec) is an oncolytic adenovirus armed with TNFa and IL2, designed to induce T-cell infiltration and cytotoxicity in solid tumors.
Patients And Methods: TUNIMO (NCT04695327) was a single-arm, multicenter phase I dose-escalation trial designed to assess the safety of TILT-123 in advanced solid cancers refractory to standard therapy. Patients received intravenous and intratumoral TILT-123.