Publications by authors named "M J van der Aa"
Background: A surrogate marker (a substitute indicator of the true outcome) is needed to predict subgroups of long-term lithium users at risk of end-stage kidney disease (ESKD). In this narrative review the aim is to determine the optimal surrogate endpoint for ESKD in long-term lithium users in a scientific context. MAIN: In a literature search in long-term lithium users, no studies on surrogate measurements on ESKD were identified.
View Article and Find Full Text PDFFundamental and translational research in ovarian cancer aims to enhance understanding of disease mechanisms and improve treatment and survival outcomes. To support this, we established the Dutch multicenter, interdisciplinary Archipelago of Ovarian Cancer Research (AOCR) infrastructure, which includes a nationwide biobank. In this study, we share our experiences in establishing the infrastructure, offer guidance for similar initiatives, and evaluate the AOCR patient cohort.
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- In the FIGO 2018 classification, women with early-stage cervical cancer are now classified differently based on their tumor's size and spread, which could change how they are treated.
- A study looked at a group of 992 women with specific types of cervical cancer to see how often the cancer spread to lymph nodes (pN+) and found that certain factors like lymphovascular space invasion (LVSI) increased the risk of spread.
- The results suggest that women with LVSI-positive tumors should have lymph node checks, but those with LVSI-negative tumors may not need this if their tumor size and other factors are considered.
Article Synopsis
- - The study investigates the antihyperglycemic effects of an ethanolic extract from plant roots, traditionally used in Uzbek medicine to manage diabetes.
- - Findings showed that the extract significantly reduced glucose levels by inhibiting reactive oxygen species, activating glucose transporters, and suppressing enzymes like α-amylase and α-glucosidase.
- - This research connects traditional healing practices with scientific evidence, highlighting the extract's potential for developing future diabetes medications.
To assess the association between pretreatment thrombocytosis, anemia, and leukocytosis and overall survival (OS) of advanced-stage EOC. Furthermore, to develop nomograms using established prognostic factors and pretreatment hematologic parameters to predict the OS of advanced EOC patients. : Advanced-stage EOC patients treated between January 1996 and January 2010 in eastern Netherlands were included.
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