Publications by authors named "M J van Egmond"
Article Synopsis
- Clinical rating scales often miss the full range of dystonic symptoms, prompting the need for a reliable biomarker to assess the effectiveness of deep brain stimulation (GPi-DBS) for treating dystonia.
- In a study of 12 patients undergoing GPi-DBS, researchers found that those with arm dystonia had higher intermuscular coherence in the 4-12 Hz range before surgery, which significantly decreased after the procedure.
- Despite the observed changes in coherence, the study found no strong links between coherence levels and clinical rating scale scores, suggesting that more research is needed to determine the biomarker's clinical utility.
Intrathecal synthesis of immunoglobulins (Igs) is a key hallmark of multiple sclerosis (MS). B cells are known to accumulate in the leptomeninges of MS patients and associate with pathology in the underlying cortex and a more severe disease course. However, the role of locally produced antibodies in MS brain pathology is poorly understood.
View Article and Find Full Text PDFBackground: Telemonitoring (TM), as part of telehealth, allows physiotherapists to monitor and coach their patients using remotely collected data. The use of TM requires a different approach compared with face-to-face treatment. Although a telehealth capability framework exists for health care professionals, it remains unclear what specific capabilities are required to use TM during physiotherapy treatments.
View Article and Find Full Text PDFObjectives: Evidence on the optimal frequency of laboratory testing during outpatient parenteral antimicrobial therapy (OPAT) is lacking. Therefore, we investigated how often and when laboratory abnormalities occur during OPAT and which factors are associated with these abnormalities.
Methods: We performed a multicenter cohort study in four Dutch hospitals among adult patients receiving OPAT and collected routinely obtained laboratory test results.
Background: Increased 4-12 Hz oscillatory activity in the cortico-basal ganglia-thalamo-cortical (CBGTC) loop is reported in dystonia. Coherence analysis is a measure of linear coupling between two signals, revealing oscillatory activity drives that are common across motor units. By performing coherence analysis, activity of the CBGTC-loop can be measured with modalities like local field potentials (LFPs), electromyography (EMG), and electro-encephalography (EEG).
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