FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis.

Lipid droplets (LDs) are organelles that store and supply lipids based on cellular needs. While mechanisms preventing oxidative damage to membrane phospholipids are established, the vulnerability of LD neutral lipids to peroxidation and protective mechanisms are unknown. Here, we identify LD-localized Ferroptosis Suppressor Protein 1 (FSP1) as a critical regulator that prevents neutral lipid peroxidation by recycling coenzyme Q10 (CoQ10) to its lipophilic antioxidant form.

Eruptive Syringoma-Clinical, Dermoscopic, and Reflectance Confocal Microscopy Features.

We present an interesting image of eruptive syringoma confirmed by histopathological assessment in a 37-year-old male who was consulted due to numerous brownish small macules and papules resembling maculopapular cutaneous mastocytosis (MPCM). We show difficulties in diagnosing ES, given its rare occurrence and resemblance to other dermatological disorders. Moreover, we discuss the role of dermoscopy and reflectance confocal microscopy in the differential diagnosis of syringoma.

Physiological Responses of Elite Cheerleaders During Training and Simulated Competition Routines.

Purpose: Competitive cheerleading (cheersport) is a physically demanding sport; however, there is a lack of information regarding its acute physiological responses during training or competition in these athletes. Thus, this study aimed to investigate these responses during both training sessions and simulated cheerleading competition routines (full-outs) among elite cheersport athletes.

Methods: Six Coed and 10 All Girl elite cheerleaders were included in this study.

Schizophrenia more employable than depression? Language-based artificial intelligence model ratings for employability of psychiatric diagnoses and somatic and healthy controls.

Artificial Intelligence (AI) assists recruiting and job searching. Such systems can be biased against certain characteristics. This results in potential misrepresentations and consequent inequalities related to people with mental health disorders.