Publications by authors named "M J Zilliox"
Article Synopsis
- Primary hypertension in children can lead to increased cardiovascular risks as they grow into adults, making early studies crucial for understanding organ damage.
- A study involving 132 youths showed significant correlations between blood pressure levels, gene expression, and molecular profiles, highlighting distinct biological changes in those with high blood pressure.
- Findings suggest that mechanisms behind elevated blood pressure could involve issues with blood vessel growth and tissue breakdown, offering potential targets for intervention in preventing long-term cardiovascular damage.
Temporal and spatial regulation of gene expression is crucial for proper embryonic development. Infrared laser-evoked gene operator (IR-LEGO) can provide information for various developmental processes. Here, we present a protocol to locally express cxcl12a during zebrafish olfactory organ development using a combination of IR-LEGO and live imaging.
View Article and Find Full Text PDFThe ocular surface microbiome is an emerging field of study that seeks to understand how the community of microorganisms found on the ocular surface may help maintain homeostasis or can potentially lead to disease and dysbiosis. Initial questions include whether the organisms detected on the ocular surface inhabit that ecological niche and, if so, whether there exists a core microbiome found in most or all healthy eyes. Many questions have emerged around whether novel organisms and/or a redistribution of organisms play a role in disease pathogenesis, response to therapies, or convalescence.
View Article and Find Full Text PDFObjective: To examine the merits of using microRNAs (miRNAs) as biomarkers of disorders of consciousness (DoC) due to traumatic brain injury (TBI).
Settings: Acute and subacute beds.
Participants: Patients remaining in vegetative and minimally conscious states (VS, MCS), an average of 1.
Gut barrier dysfunction is often implicated in pathology following alcohol intoxication and burn injury. MicroRNAs (miRNAs) are negative regulators of gene expression that play a central role in gut homeostasis, although their role after alcohol and burn injury is poorly understood. We performed an integrated analysis of miRNA and RNA sequencing data to identify a network of interactions within small intestinal epithelial cells (IECs) which could promote gut barrier disruption.
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